Optimised Commissioning of Control Systems

Pre-parameterisation of control systems facilitates their planning and commissioning
In the commissioning of control systems, coordination problems between the selected individual components occur quite frequently. Dr Egon Huefner, of Bürkert Fluid Control Systems, discusses a new, integrated controller concept with pre-parameterised control systems and defined components that prevents these problems and ensures fast, trouble-free commissioning.

Read more

Next-generation Instrument Discovers Low Affinity Inhibitors of the IP3-pathway

Traditional high-throughput screening (HTS) strategies searching for single targets have not led to a high number of promising leads for new drugs. Hence pharmaceutical companies are now increasingly looking for multi-target drugs to investigate. Dr E J Dell of BMG LABTECH explains how a next-generation photomultiplier- (PMT-) based instrument was compared to a high-performance charged coupled device (CCD), and how a next-generation HTS microplate reader provides a new more economical tool for finding lower affinity drug discovery compounds via traditional HTS bioassays.

Read more

Unfolding the Science of Senescence

The ever ageing global population has led to an increasing prevalence of protein misfolding diseases, which underlie a number of serious and chronic degenerative conditions. The misshapen structures of these abnormal proteins make them aggregation-prone, leading to the formation of toxic aggregates that underlie various disease pathologies. As the details of the science of this process continue to unfold, new therapeutic approaches to combat this fundamental mechanism of senescence are now emerging. Dr Mark Treherne, Chief Executive at Senexis, explains that as our understanding of the science underlying this fundamental pathological process continues to evolve, we will come ever closer to unfolding the fascinating science of protein senescence.

Read more

Drug Discovery: Reversed-Phase High Pressure Liquid Chromatography for Protein/Peptide Identification

Scientists typically perform unbiased protein identification by directly coupling reversed-phase high pressure liquid chromatography (HPLC) via electrospray ionisation to a mass spectrometer. Unlike innovations in mass spectrometric instrumentation, cutting-edge technology in reserved-phase HPLC has generally not been well adopted in drug discovery. Remco Swart at Thermo Fisher Scientific describes the effects of increased peak capacities on the number of identified proteins and peptides in complex mixtures utilising an RSLCnano LC system, providing a rationale for using advanced reversed-phase HPLC technology coupled with tandem mass spectrometry (HPLC-MS/MS).

Read more

United Nations Summit on Non-communicable Diseases

Non-communicable Diseases (NCDs): a global health and development challenge in the 21st century
The NCD epidemic is hitting vulnerable, socially and economically disadvantaged people the hardest. The World Economic Forum’s 2010 Global Risk Report lists NCDs as the second-greatest risk to global economic growth. One half of those who die from NCDs are in their productive years, making the social costs and economic consequences in terms of lost productivity considerable. Rebecca MORTON DOHERTY of Union for International Cancer Control (UICC) discusses that, by having the UN Summit and agreement on a political declaration on NCDs, the process of addressing NCDs globally has been set in motion in the most powerful way.

Read more

Personalised Medicine & Companion Diagnostic Device Development

Healthcare in the developed world is on the edge of a precipice. Populations are aging and healthcare costs are rising against the backdrop of uncertain economic times. Consulting the latest OECD figures shows the cost of healthcare as a percentage of GDP rising from 13.6% to 17.4%. Nick Rollings of Sagentia explores how the pharma industry itself is undergoing a period of intense change.

Read more

Moving to a Common Interpretation of eSubmission Validation Criteria?

2011 has been an interesting year for those using the ICH eCTD standard. Several agencies or groups of agencies have made changes related to their use of eCTD. The US FDA released new validation rules late in 2010 and now plans to implement them later this year. Health Canada has announced that it intends to release a new version of its Module 1 this year. In this article Charles Mathis of the LORENZ Life Sciences Group focuses on changes which have already been implemented by the European Agencies, with the implementation of new validation criteria.

Read more

Strategies for Protecting IP

In the life science industries the requirement for intellectual property rights to protect innovation is taken as a given. It is also taken as a given that those working in these industries know what intellectual property rights are and what they mean to the business. However, this is a complicated area and assumptions made may be turn out to be misguided. In this article Vicki Salmon of IP Asset LLP aims to provide an introduction to some relevant intellectual property rights and to give an indication as to how these can be strategically used for the benefit of different types of life science businesses.

Read more

The New Life Science Solution and its Implications on Document Management for Pharmaceutical Companies

The European Medicines Agency (EMA) recently announced new pharmacovigilance legislation, more commonly known as “the pharmaceutical package”. In this package the EMA describes how to modernise its pharmacovigilance system, how to improve patient safety and how to supply health information to patients. Olaf Schoepke and Gerhard Neurauter at EXTEDO explain how agencies and pharmaceutical companies can address this new legislation, along with the respective consequences for their data management.

Read more